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Home > Encyclopedia > Vardenafil hydrochloride trihydrate

Vardenafil hydrochloride trihydrate

pharmaceutical raw materials
Vardenafil hydrochloride trihydrate structure

Vardenafil hydrochloride trihydrate 

structure
  • CAS No:

    330808-88-3

  • Formula:

    C23H32N6O4S.ClH.3H2O

  • Chemical Name:

    Vardenafil hydrochloride trihydrate

  • Synonyms:

    Imidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-,hydrochloride,hydrate (1:1:3);Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-,monohydrochloride,trihydrate;Vardenafil hydrochloride trihydrate

  • Categories:

    Analytical Chemistry  >  Standard

Vardenafil hydrochloride trihydrate Basic Attributes

579.10976

578.22900

2933595960

Characteristics

121

3.63610

In water, 3.5 mg/L at 25 deg C /Estimated/

Store at 25 deg C (77 deg F), excursions permitted to 15 to 30 deg C (59 to 86 deg F), in a tight container. Protect from light.

3.4X10-19 mm Hg at 25 deg C /Estimated/

Safety Information

UN 2811 6.1 / PGIII

P264, P270, P301+P312, P330, P501

H302

Vardenafil hydrochloride trihydrate Use and Manufacturing

Selective inhibitors of phosphodiesterase 5 (PDE5), which specifically hydrolyzes cGMP, are used to study signaling through the guanylate cyclase activator nitric oxide and to mediate smooth muscle relaxation and vasodilation triggered by cGMP. Vardenafil is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, andlower urinary tract dysfunction.[Cayman Chemical]

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