1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
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1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
structure -
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CAS No:
106900-12-3
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Formula:
C29H33ClN2O3
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Chemical Name:
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
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Synonyms:
1-Piperidinebutanamide,4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-,1-oxide,trans-;R 58425;Loperamide oxide;Arestal
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CAS No:
Description
White or almost white powder, slightly hygroscopic.
Loperamide oxide is a diarylmethane.
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans- Basic Attributes
493.044
493.04
600-785-5
YWT7AJ7O7P|NG66S4H2RL
A - Alimentary tract and metabolism
2933399090
Characteristics
58.6
5.05940
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.
Safety Information
UN 2811 6.1 / PGIII
TM4960200
P201, P202, P264, P270, P273, P280, P281, P301+P310, P305+P351+P338, P308+P313, P321, P330, P337+P313, P405, P501
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P273, P280, P281, P301+P310, P305+P351+P338, P308+P313, P321, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (See all compounds classified as Antidiarrheals.)
4-((1R,4S)-4-(4-chlorophenyl)-4-hydroxy-1-oxido-1-piperidinyl)-N,N-dimethyl-2,2-diphenylbutanamide
1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans- Use and Manufacturing
Labelled Loperamide oxide (LOPOX). It is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
Computed Properties
Molecular Weight:493.0
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:492.2179706
Monoisotopic Mass:492.2179706
Topological Polar Surface Area:58.6
Heavy Atom Count:35
Complexity:668
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
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