Parbendazole
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Parbendazole
structure -
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CAS No:
14255-87-9
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Formula:
C13H17N3O2
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Chemical Name:
Parbendazole
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Synonyms:
Carbamic acid,N-(6-butyl-1H-benzimidazol-2-yl)-,methyl ester;2-Benzimidazolecarbamic acid,5-butyl-,methyl ester;Carbamic acid,(5-butyl-1H-benzimidazol-2-yl)-,methyl ester;Methyl 5(6)-butyl-2-benzimidazolecarbamate;Parbendazole;5-Butyl-2-(carbomethoxyamino)benzimidazole;SKF 29044;Methyl 5-butylbenzimidazole-2-carbamate;Helmatac;Methyl (5-butyl-1H-benzimidazol-2-yl)carbamate;Helatac;PBZ (fungicide);PBZ;52980-90-2
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CAS No:
Description
solidCrystals or fine white powder.
Crystals or fine white powder. (NTP, 1992)
Crystals or fine white powder. (NTP, 1992)|N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester is a carbamate ester and a member of benzimidazoles.
Characteristics
67
3.4
solid
1.1214 (rough estimate)
226 °C (decomp)
390.33°C (rough estimate)
1.5700 (estimate)
H2O: <0.1 g/100 mL at 18 ºC
2-8°C
Oral-rat LD50: >40 mg/kg; Oral-Mouse LD50: 1700 mg/kg
Thermal decomposition to emit toxic nitrogen oxide fumes
164.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|175.7 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]
Insoluble in water.
Amines, Phosphines, and Pyridines
PARBENDAZOLE is a carbamate ester-amine. Amines behave as chemical bases. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Safety Information
2811
3
63-22
36/37
DD6495000
Xn
Warehouse ventilated, low temperature and dry
Stable. Incompatible with strong oxidizing agents.
P280-P301 + P312 + P330
H302-H361
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Drug Information
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
helmatac
Parbendazole Use and Manufacturing
Parbendazole is a benzimidazole carbamate and a potent inhibitor of microtubule assembly and functions.
Computed Properties
Molecular Weight:247.29
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:247.132076794
Monoisotopic Mass:247.132076794
Topological Polar Surface Area:67
Heavy Atom Count:18
Complexity:285
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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