2-Chloro-6-fluoroanisole

Colorless liquid

Methyl iodide (850μl, 13.646mmol) and potassium carbonate (943mg, 6.824mmol) were added to 2-chloro-6-fluorophenol (1.0g, 6.824mmol) in tetrahydrofuran (10ml) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was partitioned between diethyl ether (50ml) and water (50ml). The organic phase was extracted and further washed with water (2 x 20ml) then dried over sodium sulphate and concentrated in vacuo to afford the title compound as a colourless liquid in 94percent yield, 1.03g.To a four-necked flask was added 30 g (0.19 mol) of 3-chloroanisidine, 30 g (1.67 mol) of water was added and the temperature was raised to 50 ° C, A solution of 36percent HC1231 g (2.28 mol)After incubation for 0.5 h, The temperature was lowered to 0 ° C, and 30percent NaN0244 was slowly added dropwise.Diazotization reaction, Upon completion of the addition, After 2h incubation, Remove the filter cake. 69.5 g (0.38 mol) of 48percent HBF4 solution was added dropwise to the filtrate, To carry out condensation reaction, Insulation lh later.The solution was filtered, The solids were dried for dehydration.The dried fluoroborate, Slowly heated to 130 ° C for cracking reaction, Until no gas is produced.After the cracking of the solution for distillation, The 2, 6-CFA fraction was collected to give 26 g of the title compound. Purity> 98.5percent, The yield of 3 steps was 85percent (from 2, 3-dichloronitrobenzene to the final target compound, The overall yield was 69.4percent).

Molecular Weight:160.57
XLogP3:2.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:160.0091207
Monoisotopic Mass:160.0091207
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes