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Sodium octanoate

Sodium octanoate structure

CAS No:
1984-06-1
Formula:
C8H16O2.Na
Chemical Name:
Sodium octanoate
Synonyms:
Octanoic acid,sodium salt (1:1);Octanoic acid,sodium salt;Sodium caprylate;Sodium octanoate;Caprylic acid sodium salt;Sodium n-octanoate;Sodium octoate
Categories:
Cosmetic Ingredient > Emulsifying Agent

Description

DryPowder; Liquid; OtherSolid

Sodium octanoate is an organic sodium salt comprising equal numbers of sodium and octanoate ions. It contains an octanoate.

Sodium octanoate Basic Attributes

Molecular Weight：

166.19

Exact Mass：

166.096970

BRN：

3597723

EC Number：

217-850-5

UNII：

9XTM81VK2B

DSSTox ID：

DTXSID3027451

HScode：

2915900090

Characteristics

PSA：

40.1

XLogP3：

-1.38 (LogP)

Appearance：

White to off-white Powder

Melting Point：

243-245 °C

Water Solubility：

H2O: soluble

Storage Conditions：

Store at RT.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

37/39-26

RTECS Number：

RH0787000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319

Disposal Methods：

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

GHS Classification：

|Warning|H315 (97.83%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 117 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Human Toxicity Values：

Mutation data reported.

Drug Information

Mechanism of Action：

SODIUM OCTANOATE (2.4 MMOL) MODIFIED THE INTRACELLULAR ACTION POTENTIAL IN ISOLATED RABBIT ATRIUM & PAPILLARY MUSCLE. THE RATE OF DEPOLARIZATION & TIME OF REPOLARIZATION WERE MARKEDLY DECREASED, BUT NO CHANGE OCCURRED IN THE RESTING MEMBRANE POTENTIAL. THE AMPLITUDE OF THE ACTION & REVERSE POTENTIAL SHOWED MODERATE DECREASES.|SODIUM PROPIONATE, SODIUM BUTYRATE, SODIUM PENTANOATE, SODIUM HEXANOATE, & SODIUM OCTANOATE AT LOW CONCN (0.1-1.0 MMOL) STIMULATED SODIUM TRANSPORT BY THE TOAD BLADDER, BUT HIGH CONCN (5-20 MMOL) REVERSIBLY INHIBITED TRANSPORT.|SODIUM OCTANOATE AT 3.69X10-7 MOL DECREASED THE INCORPORATION OF L-LEUCINE INTO NORMAL RAT LIVER SLICES & HEPATOMA CELLS BY APPROXIMATELY 75%.

MeSH Entry Terms：

caprylic acid

Sodium octanoate Use and Manufacturing

Uses

Sodium caprylate is used as a protein stabilizer in biological preparations

Corrosion inhibitors and anti-scaling agents

Cleaning and furnishing care products

Production

1,000,000 - 10,000,000 lb

Manufacturing Info：

All other basic organic chemical manufacturing|Octanoic acid, sodium salt (1:1): ACTIVE|SODIUM...PROPIONATES...INCORPORATED IN BREAD DOUGH AS NONTOXIC INHIBITORS OF MOLD GROWTH. ...PROMOTED FOR TREATMENT OF DERMATOMYCOSES. ... RELATIVELY WEAK & POSSESSES ONLY FUNGISTATIC ACTIVITY... CAPRYLIC ACID & ITS SALTS ARE SIMILAR IN ACTIONS...& ARE USED FOR THE SAME MEDICAL PURPOSES. /CAPRYLIC ACID SALTS/|THE RECTAL ABSORPTION OF PHARMACEUTICALS SUCH AS BETA-LACTAM ANTIBIOTICS OR INSULIN, IS INCREASED IN THE PRESENCE OF A C8-14 FATTY ACID OR ITS SALTS, SUCH AS SODIUM OCTANOATE, OR LEUCIC ACID.|STABILIZERS ADDED TO PREPARATIONS OF HUMAN SERUM ALBUMIN BEFORE HEAT TREATMENT WERE TESTED FOR BILIRUBIN DISPLACING EFFECT, USING THE PEROXIDASE METHOD. SODIUM CAPRYLATE DISPLACED BILIRUBIN FROM ITS COMPLEX WITH HUMAN SERUM ALBUMIN IN VITRO.

Analytic Methods：

THE ENZYMIC-COLORIMETRIC METHOD OF K MIZUNO ET AL (1980) FOR THE DETERMINATION OF FREE FATTY ACIDS WAS ADAPTED FOR THE DETERMINATION OF SODIUM CAPRYLATE IN ALBUMIN & IN GAMMA-GLOBULIN SOLUTIONS. THE METHOD IS REPRODUCIBLE, SPECIFIC, & LINEAR UP TO 6 MMOL.

Use Classification：

EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Emulsifying; Surfactant

Computed Properties

Molecular Weight:166.19
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:166.09697400
Monoisotopic Mass:166.09697400
Topological Polar Surface Area:40.1
Heavy Atom Count:11
Complexity:94.1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Downstream Products

1-Octanol

Ethyl acetate

N-Heptane

Ethanol

Isobutanol

Drug Function and Efficacy

The drug therapy classification of this product is plasma substitute and plasma protein component, ATC classification code: B05AA01. The amount of human albumin in plasma exceeds half of the total plasma protein and accounts for 10% of liver protein synthesis. Physicochemical data: 5% human albumin has a slight low colloid pressure effect on normal plasma. 20% human albumin has a relatively high colloid pressure effect. The most important physiological function of albumin is to maintain blood colloid osmotic pressure and its transport function. Albumin can maintain a stable circulating blood volume and serve as a carrier of hormones, enzymes, drugs and toxins. Toxicological effects: Human albumin is a normal component of human plasma and its role is the same as physiological albumin. In animal experiments, single-dose toxicity tests are meaningless and insufficient to evaluate toxicity, lethal doses, or dose-effect relationships. Repeated dose toxicity tests are not feasible because animal models produce antibodies to heterologous proteins. So far, human albumin has not been reported to be associated with embryotoxicity, carcinogenicity and potential mutagenicity. No acute toxicity was found in animal models.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Human serum albumin
Ingredients	Human albumin (g/100ml): 20 N-acetyltryptophan sodium: 16mmol/L Sodium carboxylate: 16mmol/L Sodium chloride: 140mmol/L Water for injection: add to volume The upper limit of aluminum content in human albumin according to the European Pharmacopoeia is not more than 200μg/L
Indication	It is not known whether human albumin has any specific interactions with other medicinal products. Human albumin should not be mixed with other medicinal products, including whole blood and red blood cell concentrates.
Specifications	10g (20%, 50ml)/bottle/box

Human serum albumin
Ingredients	Human albumin. It is extracted from healthy human plasma. Excipients: Sodium octanoate
Indication	This product should not be mixed with vasoconstrictors, proteolytic enzymes or injections containing alcoholic solvents. Because this product has a hypertonic effect, excessive injection can cause dehydration, increased circulatory load, congestive heart failure and pulmonary edema.
Specifications	20%10ml(2g/bottle)
Manufacturer	Shanxi Kangbao Biological Product Co., Ltd.

Human serum albumin
Ingredients	Human albumin 200g/L. This product is derived from human plasma. Excipients: Sodium octanoate 16mmol/L (2.7g/L) Sodium acetyltryptophan 16mmol/L (4.3g/L) Sodium chloride 3.0g/L Total sodium content 100-130mmol/L Water for injection adjusted to 1L
Indication	This product must be used alone and cannot be mixed with other drugs other than the solvent. Human albumin must not be mixed with vasoconstrictors, protein hydrolysates or solutions containing ethanol.
Specifications	10g/bottle (20%, 50ml)

See More Related Drugs

Registered Holders

Merck CHEMICALS (SHANGHAI) Co., Ltd.

China
Active
Chengdu HUAYI Pharmaceutical Excipients Manufacturing Co., Ltd.

China
Active
Hunan Jiudian HONGYANG Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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