4-(BENZYLOXY)BENZENE-1-SULFONYL CHLORIDE

1.4: 4-Benzyloxybenzenesulfonyl chloride3.5: 4-Benzyloxybenzenesulfonyl chloride; A solution of 55 ml (639 mmol) of oxalyl chloride in 250 ml of dichloromethane is added dropwise to a solution of 61 g (213 mmol) of the sodium salt of 4-benzyloxybenzenesulfonic acid in 200 ml of dimethylformamide, while maintaining the temperature between -20° C. and -10° C. After addition, the reaction medium is slowly brought back to ambient temperature and then stirred for 18 h, poured onto ice and extracted with ethyl acetate. The organic phase is washed with water and with a saturated aqueous solution of sodium chloride and concentrated under vacuum. 54 g (89percent) of 4-benzyloxybenzenesulfonyl chloride are obtained in the form of a white solid.A solution of 55 ml (639 mmol) of oxalyl chloride in 250 ml of dichloromethane is added dropwise to a solution of 61 g (213 mmol) of the sodium salt of 4-benzyloxybenzenesulfonic acid in 200 ml of dimethylformamide, while maintaining the temperature between −20° C. and −10° C. After addition, the reaction medium is slowly brought back to ambient temperature and then stirred for 18 h, poured onto ice and extracted with ethyl acetate. The organic phase is washed with water and with a saturated aqueous solution of sodium chloride and concentrated under vacuum. 54 g (89percent) of 4-benzyloxybenzenesulfonyl chloride are obtained in the form of a white solid.To a 0 °C solution of oxalyl chloride (1.93 mL, 22.8 mmol) in dry CHA mixture of sodium 4- phenoxybenzenesulfonate (1.00 g, 3.5 mmol), thionyl chloride (6.54 g, 55 mmol) and DMF (50 μ.) was heated at 70 °C for 2 hours. The reaction was cooled and concentrated at reduced pressure. The residue was dissolved in ethyl acetate (75 mL) and washed with water (3 x 25 mL), saturated aqueous NaHC0

Molecular Weight:282.74
XLogP3:3.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:282.0117431
Monoisotopic Mass:282.0117431
Topological Polar Surface Area:51.8
Heavy Atom Count:18
Complexity:336
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes