(BIS-TERT-BUTOXYCARBONYLMETHYL-AMINO)-ACETIC ACID

Compound 11 (477 mg, 1.17 mmol) was used as a starting material. By the same synthetic procedure as that for 9, 12 (335 mg, 97percent) was obtained as a pale yellow oil.Compound 11 (477 mg, 1.17 mmol) was used as a starting material. By the same synthetic procedure as that for 9, 12 (335 mg, 97%) was obtained as a pale yellow oil.Compound 7 (50 mg, 0.22 mmol) and 12 (170 mg, 0.56 mmol) were used as the starting materials. By the same synthetic procedure as that for 10, 13 ( 224 mg, quant) was obtained as a pale yellow oil.The compound of formula 10 (60 mg, 0.19 mmol) prepared in Step 2 was reacted with N-hydroxybenzotriazole (51 mg, 0.38 mmol) and 0-benzotriazole-N, N, f, N Apos; -tetramethyl-urea-hexafluorophosphate (144 mg, 0.38 mmol) was dissolved in N, f-dimethylformamide (5 mL). After stirring for 30 minutes, addition was made at room temperatureThe compound of formula 7 (47 mg, 0.13 mmol) prepared in and N, N'-diisopropylethylamine (133 mL, 0.762 mmol) were stirred at room temperature for 16 hours. N, N'-dimethylformamide was removed in vacuo, and the title compound (11) was isolated by column chromatographyThe compound of formula 9 (550 mg, 1.73 mmol) prepared in step 1 was dissolved in methanol (MeOH, 10 mL)Add 1 M lithium hydroxide (1 M LiOH, 3.4 mL, 3.4 mmol). After stirring at 50 C for 1 hour, add IN hydrochloric acid (IN HC1, 3, 8 mL, 2.2 mmol) and neutralize. The solvent was removed in vacuo to give the compound of formula 10.Palladium on carbon (10%, 15 g) was added to a degassed solution of To

Molecular Weight:303.35
XLogP3:-0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:303.16818752
Monoisotopic Mass:303.16818752
Topological Polar Surface Area:93.1
Heavy Atom Count:21
Complexity:361
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes