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Pioglitazone

Pioglitazone structure

CAS No:
111025-46-8
Formula:
C19H20N2O3S
Chemical Name:
Pioglitazone
Synonyms:
2,4-Thiazolidinedione,5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-;2,4-Thiazolidinedione,5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-,(±)-;5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione;Pioglitazone;U 72107;5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione;Zactos;5-[4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl]thiazolidine-2,4-dione;(RS)-5-(4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl)thiazolidine-2,4-dione;105355-27-9;198077-89-3
Categories:
Biochemical Engineering > Inhibitors

Description

ChEBI: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic acti ity.Pioglitazone, (±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (Actos),is an odorless, white, crystalline powder that must be convertedto a salt such as its hydrochloride before it will haveany water s

Pioglitazone Basic Attributes

Molecular Weight：

356.44

Exact Mass：

356.44

EC Number：

1308068-626-2

Characteristics

PSA：

93.6

XLogP3：

3.8

Density：

1.260±0.06 g/cm3(Predicted)

Melting Point：

183-184 °C

Boiling Point：

575.4±45.0 °C(Predicted)

Flash Point：

301.8±28.7 °C

Refractive Index：

1.611

Water Solubility：

4.42e-03 g/L

Storage Conditions：

Store at 25 deg C (77 deg F); excursions permitted to 15-30 deg C (59-86 deg F). Keep container tightly closed, and protect from moisture and humidity.

Vapor Pressure：

2.88X10-14 mm Hg at 25 deg C (est)

Safety Information

hazard class code：

11-34

safety instructions：

16-26-36/37/39-45

Marks：

F,C

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

Pioglitazone Use and Manufacturing

antihyperlipidemic, HMGCoA reductase inhibitor

Computed Properties

Molecular Weight:356.4
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:356.11946368
Monoisotopic Mass:356.11946368
Topological Polar Surface Area:93.6
Heavy Atom Count:25
Complexity:466
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Methyl acrylate

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