 Home > Encyclopedia > PJ34

PJ34

PJ34 structure

CAS No:
344458-19-1
Formula:
C17H17N3O2
Chemical Name:
PJ34
Synonyms:
N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE;PJ-34;PJ34(free base);Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide PJ 34;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide
Categories:
Biochemical Engineering > Inhibitors

Description

PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.

PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, an antiatherosclerotic agent, a cardioprotective agent, an anti-inflammatory agent and a neuroprotective agent. It is a member of phenanthridines, a secondary carboxamide and a tertiary amino compound. It is a conjugate base of a PJ34(1+).

PJ34 Basic Attributes

Molecular Weight：

295.34

Exact Mass：

295.132080

EC Number：

604-604-1

Color/Form：

Light yellow to khaki

Characteristics

PSA：

61.4

XLogP3：

0.57

Density：

1.3±0.1 g/cm3

Boiling Point：

453.3±38.0 °C at 760 mmHg

Flash Point：

227.9±26.8 °C

Refractive Index：

1.649

Critical Temperature & Pressure：

Sealed in dry,Store in freezer, under -20°C

Safety Information

wgk germany：

WGK 2

Drug Information

MeSH Entry Terms：

N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride

PJ34 Use and Manufacturing

PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.

Computed Properties

Molecular Weight:295.34
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:295.132076794
Monoisotopic Mass:295.132076794
Topological Polar Surface Area:61.4
Heavy Atom Count:22
Complexity:438
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of PJ34

Creative Enzymes Contact Supplier

US
YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

PJ34

CAS No.: 344458-19-1

Content: 0.98%

Inquiry

Learn More Other Chemicals

Sodium phenylbutyrate

1716-12-7
Afatinib dimaleate

850140-73-7
Idelalisib

870281-82-6
Lenvatinib mesylate Formula

857890-39-2
Silodosin Formula

160970-54-7
Teneligliptin Hydrobromide Formula

906093-29-6
3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione Structure

133052-90-1
2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid Structure

317318-84-6
What is Cabozantinib

849217-68-1
What is Dacomitinib

1110813-31-4

Hot Searches: price of kerosene per gallon; ammonia index price; flunarizine; soda ash na2co3; polypropylene price per ton in nigeria 2026; naphtha price

Guide of PJ34

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

PJ34

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.