Romurtide
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Romurtide
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CAS No:
78113-36-7
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Formula:
C43H78N6O13
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Chemical Name:
Romurtide
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Synonyms:
L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-;L-Lysine,N2-[N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N6-(1-oxooctadecyl)-;N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-L-lysine;Nα-Acetylmuramoyl-L-alanyl-D-isoglutaminyl-Nε-stearoyl-L-lysine;MDP-Lys(L 18);Muroctasin;Romurtide;Muroctasine;DJ 7041;Nopia;1: PN: WO2009033811 PAGE: 103 claimed protein;102604-65-9;124436-09-5;83175-69-3;94616-69-0
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CAS No:
Characteristics
305
4.36240
1.21g/cm3
176-178 °C
1198.5ºC at 760 mmHg
678.6ºC
1.544
−20°C
LD50 in male, female mice, male, female rats, dogs (mg/kg): 436, 625, 761, 801, >200 s.c. (Ono)
D20 +24.9° (c = 1 in methanol)
Safety Information
3
OL5545000
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)
MDP-Lys(L18)
Romurtide Use and Manufacturing
Compound (I) is hydrolyzed with 60% acetic acid, and the protective group is removed to obtain compound (II), and then hydrogenated to obtain compound (III). Finally, it undergoes N-acylation reaction with active ester of octadecanoic acid to obtain romotide .
Anti-leukopenia drug. Suitable for leukopenia caused by radiotherapy.
Computed Properties
Molecular Weight:887.1
XLogP3:4.4
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:35
Exact Mass:886.56268656
Monoisotopic Mass:886.56268656
Topological Polar Surface Area:305
Heavy Atom Count:62
Complexity:1360
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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