Methyl 2-[(dimethoxyphosphinyl)thio]acetate

The preparation method is liquid-liquid heterogeneous reaction between ammonium salt and methyl chloroacetate to obtain thiophosphonate. The reaction equation is shown in the figure: Add 1150kg of ammonium salt, 1300kg of methyl chloroacetate and a certain amount of phase transfer catalyst to a 1000L reactor, react at 58-64°C for 80 minutes, and then separate layers. The lower crude ester is distilled in a 1500L refining kettle, and methyl chloroacetate is distilled out for recycling, and the vacuum at the end of the distillation is controlled to be ≤93kPa and temperature ≤120°C to obtain the refined oxythiophosphate. The reaction does not generate much heat and the reaction is relatively mild. In the production process, methyl chloroacetate is used in excess, which can increase the conversion rate of ammonium salt and protect the generated oxythiophosphate.

O,O-dimethyl-S-(methoxycarbonylmethyl) phosphorothioate is referred to as oxythiophosphate, which is an intermediate of organophosphorus pesticide oxymethoate.

Molecular Weight:214.18
XLogP3:-0.2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:214.00648162
Monoisotopic Mass:214.00648162
Topological Polar Surface Area:87.1
Heavy Atom Count:12
Complexity:186
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes