Diclobutrazol

Preparation method One: tert-butyl chloroethyl ketone reacts with 1, 2, 4-triazole to produce N-tert-butylcarbonyl methylene-1, 2, 4-triazole, with a yield of ≥90%, which is mature的制造方法。 Preparation method. N-tert-butylcarbonylmethylene-1, 2, 4-triazole reacts with 2, 4-dichlorobenzaldehyde to form dichlorenone with a yield of 90% to 96%. There is a mature preparation method. After dissolving 0.02 mol of dichlorenone and 20 mL of methanol with stirring, 140 mL of an aqueous solution containing 0.06 mol of sodium bicarbonate was added. The reactant was a white emulsion, stirred and heated to reflux, and 0.04mol of insurance powder (Na2S2O4) was added in batches within 5h. After the addition, continue to stir and reflux for 2h, cool to room temperature, add 60mL of water, stir for 30min, filter, and wash the solid with a small amount of water to obtain a light gray-white solid, which is dried to obtain 6.8g of white solid, content 92.15%, yield 95.5% or more. After recrystallization from acetonitrile, white crystals were obtained, mp 149～150℃. If water-dimethylformamide is used as the solvent (1:1, volume ratio), the yield will be higher. Preparation method Di-tert-butyl bromoethyl ketone (α-bromo pinazone) is reacted with 1, 2, 4-triazole to prepare N-tert-butylcarbonylmethylene-1, 2, 4-triazole , That is 1-(1, 2, 4-triazol-1-yl)-3, 3-dimethylbutan-2-one. Then react with 2, 4-dichlorobenzyl chloride to prepare 1-(2, 4-dichlorophenyl)-2-(1, 2, 4-triazol-1-yl)-4, 4-di Methyl-pent-3-one. Finally, potassium borohydride (or sodium borohydride) is reduced to produce benzyl chlorotriazolol.

Agricultural fungicide.

Molecular Weight:328.2
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:327.0905176
Monoisotopic Mass:327.0905176
Topological Polar Surface Area:50.9
Heavy Atom Count:21
Complexity:337
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes