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Telatinib

Telatinib structure

CAS No:
332012-40-5
Formula:
C20H16ClN5O3
Chemical Name:
Telatinib
Synonyms:
2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-;4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide;Bay 57-9352;Telatinib
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR2, VEGFR3, PDGFα, and c-Kit with IC50s of 6, 4, 15 and 1 nM, respectively.

Telatinib is under investigation in clinical trial NCT03817411 (Telatinib in Combination With Capecitabine/ Oxaliplatin in 1st Line Gastric or GEJ Cancer).

Telatinib Basic Attributes

Molecular Weight：

407.85292

Exact Mass：

409.83

UNII：

18P7197Q7J

Characteristics

PSA：

102

XLogP3：

2.53

Density：

1.4±0.1 g/cm3

Boiling Point：

713.6±60.0 °C at 760 mmHg

Flash Point：

385.4±32.9 °C

Refractive Index：

1.684

Drug Information

MeSH Entry Terms：

4-(((4-((4-chlorphenyl)amino)furo(2,3-d)pyridazin-7-yl)oxy)methyl)-N-methylpyridine-2-carboxamide

Telatinib Use and Manufacturing

Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Telatinib is used therapeutically in patients with advanced solid tumors.

Computed Properties

Molecular Weight:409.8
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:409.0941671
Monoisotopic Mass:409.0941671
Topological Polar Surface Area:102
Heavy Atom Count:29
Complexity:548
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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