5-Bromo-3-(trifluoromethyl)-2(1H)-pyridinone

Step 1 : 5-Bromo-3-(trifluoromethyl)pyridin-2(1 - )-one (P45a) To a solution of 3-(trifluoromethyl)pyridin-2(1 /-/)-one (25.0 g, 0.15 mol) in AcOH (300 mL) were added NaOAc (15.1 g, 0.18 mol) and dropwise BrTo a solution of 3-(trifluoromethyl)-2(1H)-pyridinone (D15) (10 g) in tetrahydrofuran (THF) (100 mL) stirred in air at room temperature was added NBS (14.19 g) portionwise. The reaction mixture was stirred for 4 h, then diluted with water (100 mL), extracted with ethyl acetate (3*50 mL). The combined organic phases were dried over sodium sulphate and concentrated to give 5-bromo-3-(trifluoromethyl)-2(1H)-pyridinone (D16) (14 g) as yellow solid. MS (ES): CGeneral procedure: In an oven-dried vial equipped with a magnetic stirrer and a PTFE septum, [Ir{dF(CF

Molecular Weight:241.99
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:240.93501
Monoisotopic Mass:240.93501
Topological Polar Surface Area:29.1
Heavy Atom Count:12
Complexity:279
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes