 Home > Encyclopedia > 2,5-Dibromothiophene

2,5-Dibromothiophene

2,5-Dibromothiophene structure

CAS No:
3141-27-3
Formula:
C4H2Br2S
Chemical Name:
2,5-Dibromothiophene
Synonyms:
Thiophene,2,5-dibromo-;2,5-Dibromothiophene;NSC 4488
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

Description

Light Yellow Liquid

2,5-Dibromothiophene Basic Attributes

Molecular Weight：

241.928

Exact Mass：

241.93

EC Number：

221-547-3

UNII：

F0033K8CXM

NSC Number：

4488

DSSTox ID：

DTXSID3062863

HScode：

2934999090

Characteristics

PSA：

28.2

XLogP3：

3.7

Appearance：

Light Yellow Liquid

Density：

2.148 g/cm³ @ Temp: 21 °C

Melting Point：

-6 °C

Boiling Point：

210.3 °C

Flash Point：

99.4±0.0 °C

Refractive Index：

1.638

Water Solubility：

Practically insoluble in water

Storage Conditions：

0-6ºC

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN2810

wgk germany：

hazard class code：

R20/21;R28;R36/37/38;R43;R68

safety instructions：

S45-S36/37/39-S28A-S26-S36

Marks：

T+:Verytoxic;

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Danger|H300 (12.77%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P272, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2,5-Dibromothiophene Use and Manufacturing

Methods of Manufacturing

Compound 4 was prepared according to the reported process (Kellogag RM, Schaap AP, Harper ET, wynberg NDH. Acid-catalyzed brominations, deuterations, rearrangements, and debrominations of thiophenes under mild conditions. J Org Chem 1968; 33: 2902-9) .N-Bromosuccinimide (60 g, 0.33 mol) was added to a solution of thiophene (14.0 g, 0.16 mol) in 250 mL of a 50: 50 (v / v) mixture of acetic acid and chloroform. The mixture, Refluxed for 15 minutes.After cooling to room temperature, Water was added, and the mixture was extracted with chloroform.The organic phase was extracted with sodium sulfate and concentrated by evaporation under reduced pressure.The crude composition was purified by column chromatography with hexane to give the desired compound as a liquid (31.5 g, 84percent).Compound II-1 (2.42 g, 10 mmol), Compound III (1.08 g, 10 mmol), Pd(OAc) 2 (0.22 g, 1 mmol), BINAP (2, 2'-bisdiphenylphosphino-1, 1'-binaphthyl, 0.62 g, 1 mmol) and t-BuOK (2.24 g, 20 mmol) plusInto 50 mL of dry 1, 2-dimethoxyethane (DME), the reaction mixture was stirred under a nitrogen atmosphere overnight, TLC detectionThe reaction is now complete.The reaction mixture was carefully poured into 200 mL of ice water, stirred, extracted with 50 mL×3 CH 2 Cl 2 , and the combined phases were combined.It was washed with 1percent diluted hydrochloric acid and brine and dried over anhydrous sodium sulfate. The desiccant was removed by suction filtration, and the filtrate was evaporated to dryness on a rotary evaporator.The residue was purified using silica gel column chromatography.Compound IV-I, 1.88 g (yield 70percent) was obtained.

Manufacturing Info：

Thiophene, 2,5-dibromo-: ACTIVE

Computed Properties

Molecular Weight:241.93
XLogP3:3.7
Hydrogen Bond Acceptor Count:1
Exact Mass:241.82235
Monoisotopic Mass:239.82440
Topological Polar Surface Area:28.2
Heavy Atom Count:7
Complexity:58.7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2,5-Dibromothiophene

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2,5-Dibromothiophene

CAS No.: 3141-27-3

Content: 99.00%

Inquiry
Greenbo Biochem Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

2,5-Dibromothiophene 99% high quality Professional thiofuran seires Producer Greenbo

CAS No.: 3141-27-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Changzhou Xuanming Pharmaceutical Techno Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Peptides,Chemicals,API,Additives

2,5-DibromothiopheneThiophene,5-dibromo

CAS No.: 3141-27-3

Grade: Industrial Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

best price 2,5-Dibromothiophene 99% see COA kanbei

CAS No.: 3141-27-3

Content: 99%

Inquiry
NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

2,5-Dibromothiophene 3141-27-3

CAS No.: 3141-27-3

Grade: Industrial Grade

Content: 99%

Inquiry