4-Piperidinecarboxylic acid, hydrochloride (1:1)

white to cream crystalline powder

To a solution of Piperidine-4-carboxylic Acid hydrochloride (1eq), the amide was dissolved in dimethylformamide (DMF) and, morpholine (1.01 eq) and 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (EDC , 1.1 eq), 1- hydroxybenzotriazole (HOBT, 1.1 eq) was added dropwise, and triethylamine (TEA, 3 eq) sequentially. After stirring overnight at room temperature, then terminate the reaction with a small amount of water, extracted with EtOAc and water and a small amount of water in the organic layer was removed by using anhydrous MgSO4, and evaporated under reduced pressure to remove the solvent and dried in vacuo. Then, separated by column to give the title compound in 69% yield.A mixture of 1 -(ieri-butoxycarbonyl)piperidine-4-carboxylic acid (1.0 g, 4.4 mmol) in saturated EtOAc/HCI solution (10 mL) was stirred at room temperature for 2 hours. The mixture was concentrated to give the title compound (720 mg, 99%) as a white solid. LCMS- C: RT 0.72 min; m/z 130.1 [M+H]' for free baseTo a mixture of

Molecular Weight:165.62
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:165.0556563
Monoisotopic Mass:165.0556563
Topological Polar Surface Area:49.3
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes