Alamethicin
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Alamethicin
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CAS No:
27061-78-5
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Chemical Name:
Alamethicin
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Synonyms:
Alamethicin;11051-59-5;55739-76-9
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CAS No:
Description
Alamethicin, isolated from Trichoderma viride, is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes[1][2].
A cyclic nonadecapeptide antibiotic that can act as an ionophore and is produced by strains of Trichoderma viride. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Safety Information
UN 3462 6.1/PG 3
3
25
45
T
Stable.
P301 + P310
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 41 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes. (See all compounds classified as Ionophores.)|Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes. (See all compounds classified as Uncoupling Agents.)
Alamethicin
Alamethicin Use and Manufacturing
Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.
Computed Properties
Molecular Weight:1964.3
XLogP3:-1.8
Hydrogen Bond Donor Count:22
Hydrogen Bond Acceptor Count:25
Rotatable Bond Count:53
Exact Mass:1963.11424836
Monoisotopic Mass:1963.11424836
Topological Polar Surface Area:708
Heavy Atom Count:139
Complexity:4520
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes