1-(5-Amino-2-pyridinyl)-4-piperidinol

l-(5-Aminopyridin-2-yl)piperidin-4-ol [00153] A solution of l-(5-nitropyridin-2-yl)piperidin-4-ol (Example, 18B, 0.6g, 2.6 mmol) in ethanol was added 10percent palladium on carbon (0.3 g) and the mass was stirred at RT with hydrogen bladder for 3 h. Reaction mass was filtered through CELITE.(R). and concentrated to remove ethanol to yield Example 18C (0.45 g, 89percent yield) as a brown oil. LC-MS, [M+H]To a suspension of 1.35g (6.04mmol) of the compound obtained in the Manufacturing Example 73 in 18mL of ethanol and 3mL of water were added 1.3g of reduced iron and 0.25mL of conc. hydrochloric acid, and the mixture was stirred for 2 hours at 90°C. After cooling the reaction mixture, the mixture was filtrated by Celite.(R). and filtrate was condensed under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 10/1) to give 601mg (51percent) of the title compound.

Molecular Weight:193.25
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:193.121512110
Monoisotopic Mass:193.121512110
Topological Polar Surface Area:62.4
Heavy Atom Count:14
Complexity:180
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes