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Swertisin

Swertisin structure

CAS No:
6991-10-2
Formula:
C22H22O10
Chemical Name:
Swertisin
Synonyms:
4H-1-Benzopyran-4-one,6-β-D-glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-;Swertisin;6-β-D-Glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one;Flavocommelitin;6-β-D-Glucopyranosyl-4′,5-dihydroxy-7-methoxyflavone;7-O-Methylapigenin 6-C-β-D-glucopyranoside;NSC 641547;Genkwanin 6-C-glucoside;1401-51-0;16049-43-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Swertisin, a C-glucosylflavone isolated from Swertia japonica, is known to have antidiabetic, anti-inflammatory and antioxidant effects. Swertisin is an adenosine A1 receptor antagonist[1][2].

Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as a plant metabolite, an adenosine A1 receptor antagonist, an anti-inflammatory agent, an antioxidant and a hypoglycemic agent. It is a flavone C-glycoside, a monosaccharide derivative, a polyphenol, a monomethoxyflavone and a dihydroxyflavone. It derives from an apigenin.

Swertisin Basic Attributes

Molecular Weight：

462.4

Exact Mass：

446.40

Characteristics

PSA：

179.28000

XLogP3：

-1.03

Density：

1.6±0.1 g/cm3

Melting Point：

243 °C (decomp)

Boiling Point：

798.1±60.0 °C at 760 mmHg

Flash Point：

279.7±26.4 °C

Refractive Index：

1.695

Drug Information

MeSH Entry Terms：

swertisin

Computed Properties

Molecular Weight:446.4
XLogP3:0.5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:446.12129689
Monoisotopic Mass:446.12129689
Topological Polar Surface Area:166
Heavy Atom Count:32
Complexity:705
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER

CAS No.: 6991-10-2

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CAS No.: 6991-10-2

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