Luzopeptin A
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Luzopeptin A
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CAS No:
75580-37-9
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Formula:
C64H78N14O24
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Chemical Name:
Luzopeptin A
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Synonyms:
Luzopeptin A;Luzopeptin C,2,7-diacetate;3H,16H,22H,35H-Dipyridazino[6,1-l:6′,1′-b1][1,17,4,7,10,13,20,23,26,29]dioxaoctaazacyclodotriacontine,cyclic peptide deriv.;Antibiotic BBM 928A;BBM 928A;2-Quinolinecarboxamide,N,N′-[4,23-bis(acetyloxy)-4,4a,5,6,7,8,9,10,11,12,13,14,17,18,23,23a,24,25,26,27,28,29,30,31,32,33,36,37-octacosahydro-13,32-bis(1-hydroxy-1-methylethyl)-9,12,28,31-tetramethyl-5,8,11,14,18,24,27,30,33,37-decaoxo-3H,16H,22H,35H-dipyridazino[6,1-l:6′,1′-b1][1,17,4,7,10,13,20,23,26,29]dioxaoctaazacyclodotriacontine-17,36-diyl]bis[3-hydroxy-6-methoxy-,[4S-(4R*,4aR*,13R*,17S*,23R*,23aR*,32R*,36S*)]-;85255-31-8
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CAS No:
Luzopeptin A Use and Manufacturing
Luzopeptin A is a cyclic depsipeptide antibiotic first isolated from an actinomycete strain. It displays antitumor activity, as it is highly active in mice against a variety of experimental tumors. Luzopeptin A acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules. It also inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases.[Cayman Chemical]
Computed Properties
Molecular Weight:1427.4
XLogP3:-0.8
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:28
Rotatable Bond Count:12
Exact Mass:1426.53133941
Monoisotopic Mass:1426.53133941
Topological Polar Surface Area:493
Heavy Atom Count:102
Complexity:3020
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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