1,2-Benzisothiazol-5-amine

5-Nitrobenzo[d]isothiazole (305 mg, 1.69 mmol), 5percent AcOH (aq.) (12 ml.) and EtOAc (12 ml.) at 65 °C was treated with iron powder (325 mesh, 473 mg) and stirred rapidly for 1 h. The mixture was cooled to ambient temperature, diluted with water and EtOAc and filtered through dicalite. The organic layer was separated and the aqueous layer extracted with further EtOAc. The combined organic extracts were washed with brine, dried (MgSO5-Nitrobenzo[d]isothiazole (305 mg, 1.69 mmol), 5percent AcOH (aq.) (12 mL) and EtOAc (12 mL) at 65 C. was treated with iron powder (325 mesh, 473 mg) and stirred rapidly for 1 h. The mixture was cooled to ambient temperature, diluted with water and EtOAc and filtered through dicalite. The organic layer was separated and the aqueous layer extracted with further EtOAc. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated in vacuo to give the title compound as a yellow solid (220 mg, 85percent).Data for 5-aminobenzo[d]isothiazole: MS (ESI) m/z: 151 ([M+H]+).To a solution of crude lb in EtOH (20 mL) was added with iron powder (986 mg, 17.6 mmol, 3.2 eq.) and HC1 (1 mL) in one batch, heated to reflux. TLC indicated the fully consumption of lb. The mixture then firstly filtrated; the residue was extracted with EtOAc (50 mL * 2). The combined organic phase was washed with brine, dried over Na

Molecular Weight:150.20
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:150.02516937
Monoisotopic Mass:150.02516937
Topological Polar Surface Area:67.2
Heavy Atom Count:10
Complexity:129
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes