BML-286
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BML-286
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CAS No:
294891-81-9
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Formula:
C22H18N2O4
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Chemical Name:
BML-286
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Synonyms:
BML-286;2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]benzoic Acid;CHEMBL3814761;2-[[oxo-[3-[(1-oxo-2-phenylethyl)amino]phenyl]methyl]amino]benzoic acid;Oprea1_808529;2-[[3-[(phenylacetyl)amino]benzoyl]amino]benzoic Acid;SCHEMBL13870842;DTXSID20411073;CHEBI:125519;ZINC5602838
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CAS No:
Description
2-[[oxo-[3-[(1-oxo-2-phenylethyl)amino]phenyl]methyl]amino]benzoic acid is a member of benzamides.
BML-286 Use and Manufacturing
A small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways.
Computed Properties
Molecular Weight:374.4
XLogP3:3.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:374.12665706
Monoisotopic Mass:374.12665706
Topological Polar Surface Area:95.5
Heavy Atom Count:28
Complexity:559
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes