2-(broMoMethyl)-6-Methoxypyridine
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2-(broMoMethyl)-6-Methoxypyridine
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CAS No:
156094-63-2
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Formula:
C7H8BrNO
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Chemical Name:
2-(broMoMethyl)-6-Methoxypyridine
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Synonyms:
2-(Bromomethyl)-6-methoxypyridine;Pyridine, 2-(bromomethyl)-6-methoxy-;2-bromomethyl-6-methoxypyridine;SCHEMBL18705;2-Methoxy-6-bromomethylpyridine;CTK8B7342;2-bromomethyl-6-methoxy-pyridine;DTXSID00435292;KS-00000PA8;7829AA
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CAS No:
Safety Information
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, P501
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-(broMoMethyl)-6-Methoxypyridine Use and Manufacturing
1.07 g (6.01 mmol) of N-bromosuccinimide (NBS) and 49.3 mg ( 0.300 mmol) of azobisisobutyronitrile(AIBN) were mixed in 8 mL of carbon tetrachloride (CCl4) under nitrogen atmosphere. Themixture was then heated and 0.73 mL (6.00 mmol) of 2-methoxy-6-methylpyridine was added. Afterrefluxed 8 hours in oil bath, the mixture was cooled to ambient temperature. The crude was thenconcentrated in vacuo, and purified by silica-gel column chromatography [eluent: chroloform /hexane = 1:1 (v/v) ] to give 619 mg (66 percent yield) of 2-bromomethyl-6-methoxypyridine as acolorless liquid. 1H NMR (400 MHz CDCl3) δ 7.55 (dd, J = 8.2 Hz, J = 7.3 Hz, 1H), 7.32 (d, J = 7.3 Hz, 1H), 6.99 (d, J = 8.2 Hz, 1H), 4.56 (s, 2H), 3.94 (s, 3H).1.07 g (6.01 mmol) of N-bromosuccinimide (NBS) and 49.3 mg ( 0.300 mmol) of azobisisobutyronitrile(AIBN) were mixed in 8 mL of carbon tetrachloride (CCl4) under nitrogen atmosphere. Themixture was then heated and 0.73 mL (6.00 mmol) of 2-methoxy-6-methylpyridine was added. Afterrefluxed 8 hours in oil bath, the mixture was cooled to ambient temperature. The crude was thenconcentrated in vacuo, and purified by silica-gel column chromatography [eluent: chroloform /hexane = 1:1 (v/v) ] to give 619 mg (66 percent yield) of 2-bromomethyl-6-methoxypyridine as acolorless liquid. 1H NMR (400 MHz CDCl3) δ 7.55 (dd, J = 8.2 Hz, J = 7.3 Hz, 1H), 7.32 (d, J = 7.3 Hz, 1H), 6.99 (d, J = 8.2 Hz, 1H), 4.56 (s, 2H), 3.94 (s, 3H).A room temperature solution of 4-(6-(piperazin- 1 -yl)pyridin-3 -yl)-6-( 1 H-pyrazol-4- yl)pyrazolo[1, 5-a]pyridine-3-carbonitrile bis(2, 2, 2-trifluoroacetate) (Example 698, Step 1; 6 mg, 0.0162 mmol) in dry DMA (900 tL) was treated sequentially with TEA (22.6 tL, 0.162 mmol) and
Computed Properties
Molecular Weight:202.05
XLogP3:1.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:200.97893
Monoisotopic Mass:200.97893
Topological Polar Surface Area:22.1
Heavy Atom Count:10
Complexity:99.6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-(broMoMethyl)-6-Methoxypyridine
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