(±)-Bunitrolol
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(±)-Bunitrolol
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CAS No:
34915-68-9
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Formula:
C14H20N2O2
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Chemical Name:
(±)-Bunitrolol
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Synonyms:
Benzonitrile,2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-;2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]benzonitrile;1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol;1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol;Bunitrolol;1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane;dl-Bunitrolol;(±)-Bunitrolol;2-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile;83073-79-4
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CAS No:
(±)-Bunitrolol Use and Manufacturing
It is obtained by the reaction of salicylic nitrile and epoxypropane, and then the ammonolysis of tert-butylamine. Salicylic nitrile is synthesized from salicylaldehyde, first made into oxime, then treated with acetic anhydride and obtained by hydrolysis.
Beta-blockers. The effect is 4 times stronger than propranolol, and the effect on myocardial inhibition is smaller, about 1/2 of the latter. It is used to treat arrhythmias such as atrial fibrillation, supraventricular tachycardia, angina pectoris and hypertension. Listed in the Federal Republic of Germany in 1985.
Pharmaceuticals
Computed Properties
Molecular Weight:248.32
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:248.152477885
Monoisotopic Mass:248.152477885
Topological Polar Surface Area:65.3
Heavy Atom Count:18
Complexity:290
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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