Methyl 3-bromo-5-methylbenzoate

off-white powder

To a solution of Compound 1 (5 g, 0.023 mol) in SOC12 (30 mL) was added MeOH (1.104 g, 0.035 mol) under 0° C. And the solution was stirred at 80° C. for 2 h. Then the solution was cooled to 18° C. and concentrated to remove the solvent. It was washed with water (20 mL) and extracted with EA (100 mL), dried over NaPreparation 7 Step 1: To a RT solution of 3-bromo-5-methylbenzoic acid (1 g, 4.6 mmol) in MeOH/ toluene (1/5, 12 ml) was added slowly (trimethysilyl) diazomethane (2.0 M in hexanes, 2. 76 ML, 5.527 MMOL). The mixture was stirred for 2 h at RT. The solvent was evaporated under reduced pressure and the residue was diluted with EtOAc and water. The organic layer was separated and the aqueous layer was extracted twice with EtOAc. The combined organic layers were dried over NA2SO4 and concentrated. The crude material was purified by chromatography over silica gel (100percent hexane) to give the product (1.1 g, 100percent). MS M/E 230 (M+H) +.To a solution of Compound 1 (5 g, 0.023 mol) in SOC12 (30 mL) was added MeOH (1.104 g, 0.035 mol) under 0° C. And the solution was stirred at 80° C. for 2 h. Then the solution was cooled to 18° C. and concentrated to remove the solvent. It was washed with water (20 mL) and extracted with EA (100 mL), dried over NaPreparation 7 Step 1: To a RT solution of 3-bromo-5-methylbenzoic acid (1 g, 4.6 mmol) in MeOH/ toluene (1/5, 12 ml) was added slowly (trimethysilyl) diazomethane (2.0 M in hexanes, 2. 76 ML, 5.527 MMOL). The mixture was stirred for 2 h at RT. The solvent was evaporated under reduced pressure and the residue was diluted with EtOAc and water. The organic layer was separated and the aqueous layer was extracted twice with EtOAc. The combined organic layers were dried over NA2SO4 and concentrated. The crude material was purified by chromatography over silica gel (100percent hexane) to give the product (1.1 g, 100percent). MS M/E 230 (M+H) +.

Molecular Weight:229.07
XLogP3:2.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:227.97859
Monoisotopic Mass:227.97859
Topological Polar Surface Area:26.3
Heavy Atom Count:12
Complexity:170
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes