2-Chloro-5-fluoro-3,4-pyridinediamine

A mixture of 4-amino-2-chloro-5-fluoro-3-nitropyridine (0.45 g, 2.3 mmol) and 0.6 g of Raney nickel in 10 mL of anhydrous ethyl alcohol was hydrogenated at 36 psi in a Parr hydrogenation apparatus for 2 hrs when TLC showed that the starting material had disappeared. The catalyst was removed by filtration and washed carefully with ethyl alcohol (2 x 10 mL). The combined filtrate was evaporated in vacuo to give a residue, which was purified by silica gel chromatography (CHA mixture of 4-amino-2-chloro-5-fluoro-3-nitropyridine (0.45 g, 2.3 mmol) and 0.6 g of Raney nickel in 10 mL of anhydrous ethyl alcohol was hydrogenated at 36 psi in a Parr hydrogenation apparatus for 2 hrs when TLC showed that the starting material had disappeared. The catalyst was removed by filtration and washed carefully with ethyl alcohol (2 x 10 mL). The combined filtrate was evaporated in vacuo to give a residue, which was purified by silica gel chromatography (CH

Molecular Weight:161.56
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Exact Mass:161.0156030
Monoisotopic Mass:161.0156030
Topological Polar Surface Area:64.9
Heavy Atom Count:10
Complexity:124
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes