2-Chloro-4-methyl-5-nitropyridine
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2-Chloro-4-methyl-5-nitropyridine
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CAS No:
23056-33-9
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Formula:
C6H5ClN2O2
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Chemical Name:
2-Chloro-4-methyl-5-nitropyridine
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Synonyms:
Pyridine,2-chloro-4-methyl-5-nitro-;4-Picoline,2-chloro-5-nitro-;2-Chloro-4-methyl-5-nitropyridine;2-Chloro-5-nitro-4-methylpyridine;NSC 402978;2-Chloro-5-nitro-4-picoline
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CAS No:
Characteristics
58.7
2
Light cream to light brown Crystalline Powder or Chunks
1.4±0.1 g/cm3
38.5-39.5 °C
91.2 °C @ Press: 5 Torr
>230 °F
1.576
Room temperature.
0.0621mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38-20/21/22
26-37/39-36/37/39-36
Xi,Xn
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Chloro-4-methyl-5-nitropyridine Use and Manufacturing
3-((5-Amino-4-methylpyridin-2-yl)ethynyl)-7, 7-dimethyl-7, 8-dihydroquinolin-5(6H)- one [00334]A mixture of 4-methyl-5-nitropyridin-2-ol (500 mg, 3.24 mmol), POCICopper (II) chloride (10.01 g, 74.5 mmol) was dissolved in N, N-dimethylformamide (75 mL) and tine solution was warmed to 60°C. A solution of 2-amino-4-methyl-5-nitropyridine (9.50 g, 62.0 mmol) in N, N-dimethylformamide (145 mL) was added with addition funnel over 0.5 h. The reaction mixture was heated at 110°C for 16 h. The reaction mixture was cooled to room temperature and poured into 3 N aqueous hydrochloric acid (300 mL), followed by extraction with diethyl ether. The organic extract was dried over sodium sulfate and adsorbed onto silica gel for purification by column chromatography (Si02, 20: 3 t(at)(at)h(at)'(at)(at)ries'percent(at)(at)tfY(at)'(at)'(at).''(at)a'(at)(at)'(at)'(at)(at)(at)(at)e(at)9(at)(at)i(w 2-Chloro-4-methyl -5-nitropyridine was obtained as a yellow solid (2.10 g, 20percent) :
Computed Properties
Molecular Weight:172.57
XLogP3:2
Hydrogen Bond Acceptor Count:3
Exact Mass:172.0039551
Monoisotopic Mass:172.0039551
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloro-4-methyl-5-nitropyridine
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