Norcisapride
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Norcisapride
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CAS No:
83863-69-8
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Formula:
C14H20ClN3O3
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Chemical Name:
Norcisapride
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Synonyms:
Benzamide,4-amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-4-piperidinyl]-,rel-;Benzamide,4-amino-5-chloro-2-methoxy-N-(3-methoxy-4-piperidinyl)-,cis-;rel-4-Amino-5-chloro-2-methoxy-N-[(3R,4S)-3-methoxy-4-piperidinyl]benzamide;Norcisapride;(±)-Norcisapride;86718-38-9
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CAS No:
Drug Information
Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis.
Ticalopride is an isomer of the active metabolite of cisapride. Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit.
Computed Properties
Molecular Weight:313.78
XLogP3:0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:313.1193192
Monoisotopic Mass:313.1193192
Topological Polar Surface Area:85.6
Heavy Atom Count:21
Complexity:358
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes