Cirazoline
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Cirazoline
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CAS No:
59939-16-1
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Formula:
C13H16N2O
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Chemical Name:
Cirazoline
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Synonyms:
1H-Imidazole,2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-;2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole;Cirazoline;102065-34-9
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CAS No:
Description
2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole is an aromatic ether.|Cirazoline acts on a number of α adrenergic receptors. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent. Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.
Characteristics
33.62000
1.70890
white solid
1.25 g/cm3
409.5ºCat 760 mmHg
201.4ºC
1.643
H2O: >35 mg/mL
Drug Information
Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)|Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)|Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)
2-(2'-cyclopropylphenoxymethyl)imidazoline hydrochloride
Cirazoline Use and Manufacturing
Cirazoline is a potent α-1 adrenergic receptor agonist and an even more potent α-2 receptor antagonist. It is a particularly effective vasoconstricting agent.
Computed Properties
Molecular Weight:216.28
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:216.126263138
Monoisotopic Mass:216.126263138
Topological Polar Surface Area:33.6
Heavy Atom Count:16
Complexity:273
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes