8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

To the mixture of 20 (10.00 g, 45.05 mmol) and ammonium chloride (1.76 g, 32.9 mmol), aluminum chloride (11.60 g, 87.02 mmol) was added at 185 °C. After 40 min and 70 min, further portions of aluminum chloride (5.80 g, 43.5 mmol and 11.60 g, 87.02 mmol) were added and the mixture was stirred for further 23 h at the same temperature. It was poured into a slurry of ice and 3 M HCl solution under strong agitation. The resulting solution was basified (pH 14) with 40percent NaOH and extracted with diethyl ether (300 mL and 2 * 150 mL). The organic layer was dried (MgSO

Molecular Weight:204.09
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Exact Mass:203.0268547
Monoisotopic Mass:203.0268547
Topological Polar Surface Area:12
Heavy Atom Count:12
Complexity:138
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes