4,6-dichloro-3-nitropyridin-2-aMine

7(4.48 g, 27.48 mmol) was joined in batch in concentrated H2SO4(6 ml), and fuming HNO3(1.2 mL) was added slowly under 5 oC. The mixture was stirred at 5 oC for 10h. Upon completion, the reaction mixture was quenched by ice water and modified PH=7 to obtained 3.55 g of the yellow solid 4, washed in methanol(yield: 62.1percent). m.p. 208 °C. 1H-NMR (300 MHz, CDCl3), δ (ppm): 6.84 (s, 1H), 6.25 (br, 2H).a) 4, 6-Dichloro-3-nitropyridin-2-amine (A91) To 2-amino-4, 6-dichloropyridine (1.0 g, 6.1 mmol) was added concentrated HTo a concentrated H2S04 (265mL) added 4, 6- dichloropyridin-2-amine (50g, 3O6mmol, 1.Oeq) portionwise at -5 °C and stirred for 30mm followed by addition of nitric acid (16.5OmL) dropwise. Reaction mixture was allowed to stand at 0 °C for 4 days. Upon completion, reaction mixture was slowly transferred into crushed ice. Saturated NaHCO3 solution was added to pH 8. Precipitated solid was filtered off to obtain crude compound. This was purified by column chromatography and compound was eluted in 8percent ethyl acetate in hexane to get pure 1.1 (30g, 47percent).1H NMR (CDC13, 400IVIHz): 6.85 (s, 1H), 6.28 (s, 2H).

Molecular Weight:208.00
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:206.9602317
Monoisotopic Mass:206.9602317
Topological Polar Surface Area:84.7
Heavy Atom Count:12
Complexity:186
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes