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(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one

(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one structure

CAS No:
518-11-6
Formula:
C20H23NO5
Chemical Name:
(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one
Synonyms:
Benzo[a]heptalen-9(5H)-one,6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-,(7S)-;Colchiceine,N-deacetyl-N-methyl-;Demecolceine;Benzo[a]heptalen-9(5H)-one,6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-,(S)-;(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one;Colchiceine,7-deacetamido-7-(methylamino)-;Colchameine;NSC 36559;(S)-10-Hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one

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Description

Yellow Solid

(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one Basic Attributes

Molecular Weight：

357.4

Exact Mass：

357.40

NSC Number：

36559

DSSTox ID：

DTXSID50199731

Characteristics

PSA：

XLogP3：

Melting Point：

133-135 °C @ Solvent: Methanol

Storage Conditions：

-20°C Freezer

(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one Use and Manufacturing

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization.Stimulates the intrinsic GTPase activity of tubulin.Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Computed Properties

Molecular Weight:357.4
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:357.15762283
Monoisotopic Mass:357.15762283
Topological Polar Surface Area:77
Heavy Atom Count:26
Complexity:638
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of (7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one

Description
Basic Attributes
Characteristics
Use and Manufacturing
Computed Properties

(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one

SDS

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