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Diclofensine

Diclofensine structure

CAS No:
67165-56-4
Formula:
C17H17Cl2NO
Chemical Name:
Diclofensine
Synonyms:
Isoquinoline,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-;Isoquinoline,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,(±)-;4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline;Ro 8-4650;Diclofensine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.IC50 value:Target: Dopamine reuptake inhibitorThe action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyrami

Diclofensine Basic Attributes

Molecular Weight：

322.233

Exact Mass：

322.23

HScode：

2933499090

Characteristics

PSA：

12.5

XLogP3：

4.42

Density：

1.2±0.1 g/cm3

Boiling Point：

422.6±45.0 °C at 760 mmHg

Flash Point：

209.4±28.7 °C

Refractive Index：

1.591

Drug Information

MeSH Entry Terms：

diclofensine

Diclofensine Use and Manufacturing

A stimulant; inhibits reuptake of dopamine and noradrenaline, is an effective antidepressant.Compound exhibits significant addictive properties.

Computed Properties

Molecular Weight:322.2
XLogP3:4.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:321.0687196
Monoisotopic Mass:321.0687196
Topological Polar Surface Area:12.5
Heavy Atom Count:21
Complexity:354
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes