1-(3-Furanyl)-4-methyl-3-penten-1-one

164.204

164.20

O37E2Q1R62

DTXSID90207945

30.2

2.81860

Liquid

1.006g/cm3

17 °C

244.6ºC at 760 mmHg

106.5ºC

1.487

241.6 mg/L @ 25 °C (est)

MINTY SCENT /ESSENTIAL OIL OF PERILLA FRUTESCENS/

A REVIEW WITH 26 REFERENCES ON THE PULMONARY TOXICITY OF NATURALLY OCCURRING 3-SUBSTITUTED FURANS, INCLUDING THE PERILLA FRUTESCENS LUNG TOXIN EGOMAKETONE.[WILSON BJ ET AL; PULMONARY TOXICITY OF NATURALLY OCCURRING 3-SUBSTITUTED FURANS; EFF POISONOUS PLANTS LIVEST (PROC JT US AUST SYMP POISONOUS PLANTS) 311 (1978)]

LD50 MICE INTRAPERITONEAL 6 MG/KG MALES /PERILLA KETONE/|LD50 MICE INTRAPERITONEAL 2.5 MG/KG FEMALES /PERILLA KETONE/|LD50 MICE ORAL 16 MG/KG FEMALES /PERILLA KETONE/|LD50 RATS INTRAPERITONEAL 10 MG/KG MALES /PERILLA KETONE/|LD50 RATS ORAL 25 MG/KG MALES /PERILLA KETONE/

THE ESSENTIAL OIL OF PERILLA FRUTESCENE CONTAINS AT LEAST THREE POTENT LUNG EDEMAGENIC AGENTS, KNOWN AS PERILLA KETONE, EGOMAKETONE, & ISOEGOMAKETONE, /WHICH HAVE/...STRUCTURAL SIMILARITIES TO SWEET POTATO LUNG TOXINS...

STUDIES ON THE MECHANISM OF PERILLA KETONE TOXICITY ARE UNDER WAY WHICH, ALTHOUGH INCOMPLETE, SUGGEST THAT WITH FEW EXCEPTIONS, THE MECHANISM OF ITS TOXIC ACTION IS VERY SIMILAR TO THAT OF 4-IPOMEANOL. /PERILLA KETONE/

PERILLA LUNG TOXINS MAY BE EXTRACTED FROM THE LEAVES, STEMS, & ROOTS OF THE PLANT USING A VARIETY OF ORGANIC SOLVENTS. THE RESPECTIVE COMPOUNDS, /INCLUDING EGOMAKETONE/, CAN BE SEPARATED USING HPLC & HIGH-VACUUM DISTILLATION PROCEDURES. BOTH HPLC & GAS-LIQUID CHROMATOGRAPHY MAY BE UTILIZED FOR QUANTITATIVE ANALYSES.