 Home > Encyclopedia > 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate

5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate

5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate structure

CAS No:
334827-98-4
Formula:
C23H33N7O5S.C6H6O3S
Chemical Name:
5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate
Synonyms:
5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate;Gisadenafil besylate;5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate besylate salt;Gisadenafil besylate salt;UK 369003-26

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5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate Basic Attributes

Molecular Weight：

678

Exact Mass：

677.23

UNII：

T4S08274OY

DSSTox ID：

DTXSID20187125

Characteristics

PSA：

202

XLogP3：

4.08600

Appearance：

white to off-white

Water Solubility：

DMSO: >35mg/mL

Storage Conditions：

Desiccate at RT

Safety Information

wgk germany：

Precautionary statement(s)：

P201, P202, P273, P281, P308+P313, P405, P501

Hazard Statements：

H361

Drug Information

MeSH Entry Terms：

1-(6-ethoxy-5-(3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo(4,3-d)pyrimidin-5-yl)-3-pyridyl sulphonyl)-4-ethylpiperazine

5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate Use and Manufacturing

Gisadenafil (UK 369003) is a PDE5 inhibitor. It is 80 fold selective over PDE6, and greater than 3000 fold selective over PDEs 1-4 and 7. Gisadenafil is used for the treatment of LUTS.

Computed Properties

Molecular Weight:677.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:11
Exact Mass:677.23015357
Monoisotopic Mass:677.23015357
Topological Polar Surface Area:202
Heavy Atom Count:46
Complexity:1070
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate

Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties

5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-onebenzenesulfonate

SDS

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