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Levofloxacin

Levofloxacin structure

CAS No:
100986-85-4
Formula:
C18H20FN3O4
Chemical Name:
Levofloxacin
Synonyms:
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,(3S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid,9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,(S)-;(3S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid;(-)-Ofloxacin;(S)-Ofloxacin;DR 3355;(S)-(-)-Ofloxacin;Levofloxacin;HR 355;RWJ 25213-097;Tavanic;Levaquin;Cravit;Quixin;Oftaquix;Loxof;MP 376;Unibiotic;Venaxan;Levoflox;Lexoflon;Iquix;Quinsair
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.Target: AntibacterialLevofloxacin reduced bacterial load compared with placebo by 4.9-fold (95% confidence interval, 1.4-25.7; P=0.02) at day 7 but had no effect at any point on any marker of neutrophilic airway inflammation. In patients with a baseline bacterial load of more than 10(6) cfu/mL, levofloxacin treatment was associated

Levofloxacin Basic Attributes

Molecular Weight：

361.36800

Exact Mass：

361.37

EC Number：

600-146-0

HScode：

2934999090

Characteristics

PSA：

75.01000

XLogP3：

-0.4

Appearance：

Solid

Density：

1.48 g/cm3

Melting Point：

225-227 °C (decomp)

Boiling Point：

571.5ºC at 760 mmHg

Flash Point：

299.4ºC

Refractive Index：

1.670

Water Solubility：

H2O: Insoluble

Storage Conditions：

Store at 0-5ºC

Vapor Pressure：

9.8X10-13 mm Hg at 25 deg C (est)

Specific rotation：

Specific optical rotation: -76.9 deg at 23 °C/D ( c = 0.385 in 05N NaOH)

PKA：

6.25None

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22

safety instructions：

S26; S36/37/39; S36

RTECS Number：

UU8815550

Marks：

Precautionary statement(s)：

P261-P263-P280-P342 + P311

Hazard Statements：

H302-H317-H334-H361d-H362

Levofloxacin Use and Manufacturing

This product has a broad-spectrum antibacterial effect, which is a powerful antibacterial effect. This product is ofloxacin L-body, its antibacterial activity in vitro is about twice that ofloxacin. Its mechanism of action is to inhibit bacterial DNA gyrase activity, prevent bacterial DNA synthesis and replication and cause bacterial death.

Computed Properties

Molecular Weight:361.4
XLogP3:-0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:361.14378429
Monoisotopic Mass:361.14378429
Topological Polar Surface Area:73.3
Heavy Atom Count:26
Complexity:634
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

1-Methylpiperazine

L-Ascorbic acid

Dimethyl sulfoxide

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Levofloxacin

Levofloxacin Sodium Chloride Injection
Ingredients	Levofloxacin
Indication	This product cannot be used in the same infusion tube with multivalent metal ion solutions such as magnesium and calcium. Avoid using it simultaneously with theophylline. If it is necessary to use it simultaneously, the blood concentration of theophylline should be monitored and the dosage should be adjusted accordingly. When used simultaneously with warfarin or its derivatives, the prothrombin time or other coagulation tests should be monitored. When used simultaneously with non-steroidal anti-inflammatory drugs, convulsions may be induced. When used simultaneously with oral hypoglycemic drugs, hypoglycemia may be caused. Therefore, blood sugar concentration should be monitored during medication. Once hypoglycemia occurs, this product should be discontinued immediately and appropriate treatment should be given.
Specifications	150ml: 0.75g levofloxacin and 1.35g sodium chloride
Manufacturer	Beijing Jiluohua Pharmaceutical Co., Ltd.

Diclofenac diethylamide
Ingredients	Levofloxacin.
Indication	1 Urine alkalinizing agents can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2 When quinolone antibiotics are used in combination with theophylline, competitive inhibition with the cytochrome P450 binding site may lead to a significant reduction in the liver elimination of theophylline, prolonged blood elimination half-life (t1/2()), increased blood concentration, and symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, agitation, convulsions, palpitations, etc. Although this product has little effect on the metabolism of theophylline, theophylline blood concentration should still be measured and the dosage adjusted when used in combination. 3 When this product is used in combination with cyclosporine, the blood concentration of cyclosporine can be increased. The blood concentration of cyclosporine must be monitored and the dosage adjusted. 4 Although this product has a small enhancement on the anticoagulant warfarin when used in combination, the patient's prothrombin level should also be closely monitored when used in combination. time. 5 Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used together, it may cause toxicity due to the increased blood concentration of this product. 6 This product can interfere with the metabolism of caffeine, thereby reducing the elimination of caffeine, prolonging the blood elimination half-life (t1/2beta;), and may produce central nervous system toxicity. 7 Antacids and iron preparations containing aluminum and magnesium can reduce the oral absorption of this product and should not be used together. 8 When this product is used in combination with the non-steroidal anti-inflammatory drug fenbufen, convulsions occasionally occur, so it is not suitable for use with fenbufen. 9 This product may cause blood sugar disorders when used in combination with oral hypoglycemic drugs. Therefore, blood sugar concentrations should be monitored during medication. Once hypoglycemia occurs, this product should be discontinued immediately and appropriate treatment should be given.
Manufacturer	Qinhuangdao Zizhu Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

CHROMO LABORATORIES INDIA PRIVATE LTD

United States
Active
MSN LIFE SCIENCES PRIVATE LTD

United States
Active
HEC PHARM CO LTD

United States
Active

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