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DHQHS 2

DHQHS 2 structure

CAS No:
71939-50-9
Formula:
C15H24O5
Chemical Name:
DHQHS 2
Synonyms:
Dihydroartemisinin 71939-50-9;Dihydroartemisinin (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;]hexadecan-6-ol;Dihydroarteminisin;Dihydroartemisin;(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;Alaxin;b-Dihydroartemisinin
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Description

Dihydroartemisinin is a potent anti-malaria agent.

White Solid

ChEBI: Artenimol is an artemisinin derivative.

DHQHS 2 Basic Attributes

Molecular Weight：

284.35

Exact Mass：

284.35

DSSTox ID：

DTXSID5045962

Color/Form：

White to Almost white

ATC Code：

P01BF05|P - Antiparasitic products, insecticides and repellents

HScode：

29329990

Characteristics

PSA：

57.15000

XLogP3：

2.18670

Appearance：

solid

Density：

1.24

Melting Point：

144-149°C

Boiling Point：

375.6±42.0 °C(Predicted)

Flash Point：

181.0±27.9 °C

Refractive Index：

1.543

Storage Conditions：

2-8°C

PKA：

12.61±0.70(Predicted)

Critical Temperature & Pressure：

Inert atmosphere,2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

KD4165550

GHS Classification：

|Warning|H242 (100%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]|P210, P220, P234, P273, P280, P370+P378, P391, P403+P235, P411, P420, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Eurartesim is indicated for the treatment of uncomplicated Plasmodium falciparum malaria in adults, children and infants 6 months and over and weighing 5 kg or more.Consideration should be given to official guidance on the appropriate use of antimalarial agents.|Treatment of uncomplicated malaria caused by Plasmodium falciparum

MeSH：

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

MeSH Entry Terms：

3alpha-hydroxydeoxydihydroartemisinin

DHQHS 2 Use and Manufacturing

Methods of Manufacturing

LiBHEtSodium borohydride (2.02 g, 53.19 mmol) was added in five portions within 30 minutes to the solution of artemisinin (5 g, 17.73 mmol) in methanol (60 mL) under 5. The reaction mixture was kept stirring for approximately 1h at 0–5, the acetic acid was added to adjust PH =7.0. The reaction solution was concentrated to remove most of methanol, diluted with cold water (60 mL) and stirred for 15 min at room temperature. The precipitate was collected, washed with water (20 mL*3) and dried to afford product as white solid, 4.51 g, yield: 89.57percent.Dihydroartemisinin (DHA) synthesis:Artemisinin (5.0 g, 18 mmol) was dissolved in anhydrous methanol (120 mL).It was placed in an ice water bath, and NaBH4 (1.0 g, 27 mmol) was added portionwise with stirring, and was added over 20 min. The reaction is about 2 hours, and the reaction is completed.Adjust pH 6-7 with glacial acetic acid and distill off most of the methanol.Stir with water for 15 min, filter and collect the precipitate.Wash three times with water, dry, Obtained as a white solid (3.0 g, 59percent).

Uses

The main metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite

Use Classification：

Human drugs -> Eurartesim -> EMA Drug Category|Antiprotozoals -> Human pharmacotherapeutic group|Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans

Drug Function and Efficacy

It has a strong killing effect on the asexual body of malarial parasites and can quickly kill malarial parasites, thereby quickly controlling symptoms.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dihydroartemisinin piperaquine tablets
Specifications	Each tablet contains 40 mg of dihydroartemisinin and 0.32 g of piperaquine phosphate
Manufacturer	KBN-ZHEJIANG Pharmaceutical Co., Ltd.

Dihydroartemisinin
Manufacturer	China Resources 39 (Youyang) Pharmaceutical Co., Ltd.

Compound Dihydroartemisinin Tablets
Ingredients	Main ingredients: This product contains dihydroartemisinin, piperaquine phosphate and trimethoprim.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Dihydroartemisinin 32mg, piperaquine phosphate 320mg, trimethoprim 90mg
Manufacturer	Chongqing Tonghe Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Zhejiang NHU Company Ltd.

China
Active
Guilin Pharmaceutical Co., Ltd.

China
Active
China Resources Sanjiu (Youyang) Pharmaceutical Co., Ltd.

China
Active

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