PTC-209(PTC209
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PTC-209(PTC209
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CAS No:
315704-66-6
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Formula:
C17H13Br2N5OS
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Chemical Name:
PTC-209(PTC209
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Synonyms:
PTC-209 (PTC209;PTC-209;N-(2,6-dibroMo-4-Methoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyriMidin-3-yl)thiazol-2-aMine;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine;N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine PTC-209;PTC-209, >=98%;2-THIAZOLAMINE, N-(2,6-DIBROMO-4-METHOXYPHENYL)-4-(2-METHYLIMIDAZO[1,2-A]PYRIMIDIN-3-YL)-;PTC-209 free base
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CAS No:
PTC-209(PTC209 Use and Manufacturing
Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 μM) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth. It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.[Cayman Chemical]
Computed Properties
Molecular Weight:495.2
XLogP3:5.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:494.91871
Monoisotopic Mass:492.92076
Topological Polar Surface Area:92.6
Heavy Atom Count:26
Complexity:480
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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