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Home > Encyclopedia > 9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one structure

9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one 

structure
  • CAS No:

    74991-91-6

  • Formula:

    C15H10N2O2

  • Chemical Name:

    9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

  • Synonyms:

    6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one,9-methoxy-;9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one;9-Methoxycanthin-6-one

Description

9-methoxycanthin-6-one is an indole alkaloid that is the 9-methoxy derivative of canthin-6-one. Isolated from Eurycoma longifolia and Simaba multiflora, it exhibits cytotoxic activity towards human cancer cell lines. It has a role as a metabolite, an antineoplastic agent and an antiplasmodial drug. It is an indole alkaloid, an aromatic ether and an organic heterotetracyclic compound. It derives from a canthin-6-one.

9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one Basic Attributes

250.25

250.25

DTXSID90432290

2933990090

Characteristics

43.60000

2.44730

1.40±0.1 g/cm3

180.1 °C

384.1±42.0 °C(Predicted)

4.49±0.20

Drug Information

9-methoxy-canthin-6-one

9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one Use and Manufacturing

9-Methoxycanthin-6-one is a canthin-6-one alkaloid from the intact plant parts and callus cultures of Eurycoma longifolia (Tongkat Ali). Canthin-6-one alkaloids were evaluated for their cytotoxic activity against a HT-1080 human fibrosarcoma cell line.

Computed Properties

Molecular Weight:250.25
XLogP3:2.4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:250.074227566
Monoisotopic Mass:250.074227566
Topological Polar Surface Area:44.1
Heavy Atom Count:19
Complexity:422
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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