N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
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![N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/9d6b6439cdee4a11aa7031457442da57.png "N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine")
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
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CAS No:
916603-07-1
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Formula:
C17H16FN5
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Chemical Name:
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
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Synonyms:
DianilinopyriMidine_01;CZC 00008004;N-(4-broMophenyl)-N-(naphthalen-2-yl);N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-pyrimidinediamine;N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine;N-(4-broMophenyl)-N-(naphthalen-2-yl) naphthalen-1-aMine;CZC-8004;Target-5 (Kinase Probe Tool, APM-1)/Dianilinopyrimidine_01
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CAS No:
Description
CZC8004 is an aminopyrimidine and an organofluorine compound. It has a role as a protein kinase inhibitor.
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine Basic Attributes
309.34
309.13897369
DTXSID10580580
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine Use and Manufacturing
CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.
Computed Properties
Molecular Weight:309.34
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:309.13897369
Monoisotopic Mass:309.13897369
Topological Polar Surface Area:75.9
Heavy Atom Count:23
Complexity:342
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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