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(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID

(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID structure

CAS No:
251565-85-2
Formula:
C20H24O7S
Chemical Name:
(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID
Synonyms:
2-Ethoxy-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionicacid;(αS)-α-Ethoxy-4-[2-[4-[(Methylsulfonyl)oxy]phenyl]ethoxy]benzenepropanoic Acid;(alphaS)-alpha-Ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]benzenepropanoic acid;(S)-2-ethoxy-3-[4-(2-{4-Methanesulphonyloxyphenyl}ethoxy)phenyl]propanoic acid;(S)-2-Ethoxy-3-(4-(4-((Methylsulfonyl)oxy)phenethoxy)phenyl)propanoic acid;Benzenepropanoic acid, .alpha.-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-, (.alpha.S)-;(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID;TESAGLITAZAR

Description

Tesaglitazar is a dual peroxisome proliferator-activated receptor alpha/gamma agonist which improves apolipoprotein levels in non-diabetic subjects with insulin resistance. Tesaglitazar is a proposed treatment for type 2 diabetes and has completed several phase III clinical trials, however in May 2006 AstraZeneca announced that they had discontinued further development.|Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) agonist, with hypoglycemic activity. Tesaglitazar is more potent on the gamma subtype than on the alpha subtype of PPAR. This agent improves atherogenic dyslipidemia but may cause an increase in fibrosarcoma formation.

White Solid

(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Basic Attributes

Molecular Weight：

408.47

Exact Mass：

408.47

UNII：

6734037O3L

DSSTox ID：

DTXSID4048773

NCI Thesaurus Code：

C75985

Color/Form：

White

Characteristics

PSA：

108 Å²

Density：

1.278

Melting Point：

83-85°C

Boiling Point：

611℃

PKA：

3.62±0.10(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

WGK 3

Storage features：

Desiccate at RT

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Investigated for use/treatment in diabetes mellitus type 2.

Pharmacology：

Treatment with tesaglitazar lowered fasting plasma glucose, improved glucose tolerance, substantially reduced fasting and postload insulin levels, and markedly lowered fasting TG and improved lipid tolerance.

MeSH Entry Terms：

(S)-2-ethoxy-3-(4-((4-(methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid

(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Use and Manufacturing

Dual -acting peroxisome proliferator-activated receptor (PPAR) α and γ agonist. Antidiabetic.

Computed Properties

Molecular Weight:408.5
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:408.12427427
Monoisotopic Mass:408.12427427
Topological Polar Surface Area:108
Heavy Atom Count:28
Complexity:556
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Tesaglitazar

CAS No.: 251565-85-2

Content: 99.00%

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Guide of (S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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