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11-KetoOxcarbazepine

11-KetoOxcarbazepine structure

CAS No:
537693-29-1
Formula:
C15H10N2O3
Chemical Name:
11-KetoOxcarbazepine
Synonyms:
11-Keto Oxcarbazepine;10,11-dioxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide;Oxcarbazepine-002;10,11-Dihydro-10,11-dioxo CarbaMazepine;10,11-Dihydro-10,11-dioxo-5H-dibenz[b,f]azepine-5-carboxaMide;Oxcarbazepine Impurity 9（Oxcarbazepine EP Impurity I）;Oxcarbazepine Impurity F;5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10,11-dioxo-

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11-KetoOxcarbazepine Basic Attributes

Molecular Weight：

266.25

Exact Mass：

266.06914219

UNII：

545F679M12

DSSTox ID：

DTXSID00202042

Characteristics

Density：

1.429±0.06 g/cm3

Boiling Point：

482.6±38.0 °C(Predicted)

PKA：

13.51±0.20

11-KetoOxcarbazepine Use and Manufacturing

A keto impurity of the anticonvulsant Oxcarbazepine (O869250).

Computed Properties

Molecular Weight:266.25
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:266.06914219
Monoisotopic Mass:266.06914219
Topological Polar Surface Area:80.5
Heavy Atom Count:20
Complexity:414
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an anticonvulsant and a specific analgesic for trigeminal neuralgia. It may work by inhibiting polysynaptic effects and blocking post-tetanic enhancement, significantly reducing or eliminating the pain caused by stimulation of the infraorbital nerve in rats and cats, and reducing the thalamic potential, medulla oblongata and polysynaptic reflexes (including glossomaxillary reflex) in cats. Its main metabolite, carbamazepine-10, 11-epoxide, shows anticonvulsant effects in some epilepsy model animals.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Carbamazepine sustained-release capsules
Ingredients	Chemical name: 5H-dibenzo(b,f)azepine-5-carboxamide Molecular weight: C15H12N2O
Indication	1. Because carbamazepine induces the hepatic monoamine oxidase system, this product can reduce or even eliminate the activity of certain drugs. Such as oxazepam, clonazepam, ethosuximide, primidone, valproic acid, triazolam, corticosteroids, cyclosporine, digoxin, doxycycline, haloperidol, imipramine, methadone, oral contraceptives, theophylline, and oral anticoagulants. The corresponding indicators should be measured and the dosage should be adjusted. 2. When used in combination with acetaminophen, especially a single overdose or a long-term large dose, the risk of liver poisoning increases and the efficacy of the latter is reduced. Concomitant treatment with remifentanil will cause increased hepatotoxicity. 3. The following drugs can increase the concentration of carbamazepine in plasma: erythromycin, triacetyloleandomycin, josamycin, remifentanil, pentylurea, diltiazem, dextropropoxyphene, ethoxyphenoxymethoxazole, fluoxetine, methyl
Specifications	0.1g
Manufacturer	Topfond Pharmaceutical Co., Ltd.

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Guide of 11-KetoOxcarbazepine

Basic Attributes
Characteristics
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs

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