Succinobucol
-
Succinobucol
structure -
-
CAS No:
216167-82-7
-
Formula:
C35H52O5S2
-
Chemical Name:
Succinobucol
-
Synonyms:
Butanedioic acid,1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] ester;Butanedioic acid,mono[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] ester;AGI 1067;Probucol monosuccinate;Succinobucol
-
CAS No:
Description
Succinobucol is a benzoate ester and a member of phenols.|AGI-1067, is a novel small molecule with anti-oxidant and anti-inflammatory properties that was discovered by AtheroGenics and designed to treat atherosclerosis of the blood vessels of the heart, or coronary artery disease.
Characteristics
134.43000
9.97290
1.13±0.1 g/cm3
659.5±55.0 °C(Predicted)
352.7ºC
1.571
2.71E-18mmHg at 25°C
4.27±0.17
Drug Information
Investigated for use/treatment in atherosclerosis, coronary artery disease, diabetes mellitus type 2, and in-stent restenosis.
AGI-1067 works by inhibiting key oxidant signals within cells of blood vessel walls that generate inflammatory processes that are key to the pathogenesis of atherosclerosis. This includes inhibition of inflammatory cytokines, chemokines and vascular adhesion molecules that participate in the initiation, growth and eventual destabilization of the plaque. Its anti-oxidant properties also play a role in its ability to inhibit the formation of oxidized LDL, a critical component in the formation of atherosclerotic plaque.
AGI 1067
Computed Properties
Molecular Weight:616.9
XLogP3:10.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:13
Exact Mass:616.32561710
Monoisotopic Mass:616.32561710
Topological Polar Surface Area:134
Heavy Atom Count:42
Complexity:870
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Request for Quotation