3-(4-Dimethylaminobenzylidenyl)-2-indolinone
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3-(4-Dimethylaminobenzylidenyl)-2-indolinone
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CAS No:
5812-07-7
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Formula:
C17H16N2O
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Chemical Name:
3-(4-Dimethylaminobenzylidenyl)-2-indolinone
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Synonyms:
2H-Indol-2-one,3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-;2-Indolinone,3-[p-(dimethylamino)benzylidene]-;3-[[4-(Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one;SU 4312;3-(4-Dimethylaminobenzylidenyl)-2-indolinone;NSC 86429;DMBI;3-[[4-(Dimethylamino)phenyl]methylidene]-2,3-dihydro-1H-indol-2-one
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CAS No:
Description
SU4312 is a member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. It has a role as an angiogenesis inhibitor, an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a geroprotector and a neuroprotective agent. It is a member of oxindoles, a tertiary amino compound and a substituted aniline.
Characteristics
32.34000
3.38330
1.219±0.06 g/cm3
225-232 °C
497.1±45.0 °C(Predicted)
254.5ºC
1.683
12.89±0.20
Computed Properties
Molecular Weight:264.32
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:264.126263138
Monoisotopic Mass:264.126263138
Topological Polar Surface Area:32.3
Heavy Atom Count:20
Complexity:394
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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