3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
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3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
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CAS No:
289483-69-8
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Formula:
C17H12N4O2S
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Chemical Name:
3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
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Synonyms:
E7820;
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CAS No:
Description
E7820 has been investigated for the treatment of Colon Cancer and Rectal Cancer.|Integrin alpha-2 Inhibitor E7820 is a small molecule and aromatic sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells. Inhibition of integrin alpha 2 leads to an inhibition of cell-cell interactions, endothelial cell-matrix interactions, vascular endothelial cell proliferation and angiogenesis.
3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide Basic Attributes
336.36800
336.06809681 g/mol
TVH5K7949N
719239
DTXSID20183142
C61501
Computed Properties
Molecular Weight:336.4
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:336.06809681
Monoisotopic Mass:336.06809681
Topological Polar Surface Area:118
Heavy Atom Count:24
Complexity:668
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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