2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
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![2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/7cf114186ea440dca54719ab04388af0.png "2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid")
2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
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CAS No:
136381-85-6
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Formula:
C20H14ClN3O3S
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Chemical Name:
2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
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Synonyms:
1H-Indole-1-acetic acid,2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]carbonyl]-;2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid;SR 27897;Lintitript;SR 27897B;2-[2-[[4-(2-Chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]acetic acid hydrate;[2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl]-acetic acid;2-(2-((4-(2-Chlorophenyl)thiazol-2-yl)carbamoyl)-1H-indol-1-yl)acetic acid;1435934-52-3
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CAS No:
Description
2-[2-[[[4-(2-chlorophenyl)-2-thiazolyl]amino]-oxomethyl]-1-indolyl]acetic acid is an indolyl carboxylic acid.|Lintitript is a new, highly specific and potent CCK-A receptor antagonist.
2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid Basic Attributes
411.86100
411.86
3YFV00531K
DTXSID9046738
Drug Information
For the treatment of pancreatic cancer and appetite disorders.
Lintitript SR 27897 is a selective cholecystokinin type A (CCK-A) receptor antagonist. In February 2000, Sanofi announced that it was halting development of the drug for appetite disorders, and in September 2002, Sanofi announced that it had stopped investigation all together.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. (See all compounds classified as Hormone Antagonists.)
Cholecystokinin (CCK) modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. Lintitript antagonizes the effect of cholecystokinin by binding to the cholecystokinin type A (CCK-A) receptor. This action presumably alters feeding habits, however the exact mechanism of action is not known.
1-((2-(4-(2-chlorophenyl)thiazol-2-yl)aminocarbonyl)indolyl)acetic acid
Computed Properties
Molecular Weight:411.9
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:411.0444402
Monoisotopic Mass:411.0444402
Topological Polar Surface Area:113
Heavy Atom Count:28
Complexity:595
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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