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Pozanicline

Pozanicline structure

CAS No:
161417-03-4
Formula:
C11H16N2O
Chemical Name:
Pozanicline
Synonyms:
Pyridine,2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-;Pyridine,2-methyl-3-(2-pyrrolidinylmethoxy)-,(S)-;2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]pyridine;ABT 089;(S)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine;A 87089.0;Pozanicline;2-Methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine

Description

ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for the treatment of several neurological disorders including Alzheimer, Attention Deficit Hyperactivity Disorder and Schizophrenia/Schizoaffective disorders. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes. Neuronal nicotinic acetylcholine receptors (nAChRs) modulate the release of several important neurotransmitters, such as acetylcholine and dopamine.

Pozanicline Basic Attributes

Molecular Weight：

192.25800

Exact Mass：

192.26

UNII：

CL2002R563

DSSTox ID：

DTXSID20167149

Characteristics

PSA：

34.15000

XLogP3：

1.84960

Density：

1.046g/cm3

Boiling Point：

302.7ºC at 760mmHg

Flash Point：

136.9ºC

Refractive Index：

1.517

Vapor Pressure：

0.000975mmHg at 25°C

Toxicity

Toxicity Summary：

ABT-089 was shown to be well-tolerated in clinical trials.

Drug Information

Drug Indication：

Investigated for use/treatment in Alzheimer's disease, Attention Deficit/Hyperactivity Disorder (ADHD), and Schizophrenia and schizoaffective disorders.

Pharmacology：

ABT-089 is a neuronal nicotinic acetylcholine receptor agonist. Neuronal nicotinic acetylcholine receptors (nAChRs) modulate the release of several important neurotransmitters, such as acetylcholine and dopamine.

Mechanism of Action：

ABT-089 is a neuronal nicotinic acetylcholine receptor agonist. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes.

MeSH Entry Terms：

2-methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride, (R)-isomer

Computed Properties

Molecular Weight:192.26
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:192.126263138
Monoisotopic Mass:192.126263138
Topological Polar Surface Area:34.2
Heavy Atom Count:14
Complexity:175
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Pozanicline

Description
Basic Attributes
Characteristics
Toxicity
Drug Information
Computed Properties

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