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Home > Encyclopedia > 4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone

4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone

4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone structure

4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone 

structure
  • CAS No:

    688007-26-3

  • Formula:

    C9H13N3O5

  • Chemical Name:

    4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone

  • Synonyms:

    2(1H)-Pyrimidinone,4-amino-1-pentofuranosyl-;4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone

Description

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone Basic Attributes

243.22 g/mol

243.22

287459|249004|20258

Characteristics

129 Ų

Drug Information

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)|Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

Ara C

4-Amino-1-pentofuranosyl-2(1H)-pyrimidinone Use and Manufacturing

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:243.22
XLogP3:-2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:243.08552052
Monoisotopic Mass:243.08552052
Topological Polar Surface Area:129
Heavy Atom Count:17
Complexity:383
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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