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Lificiguat

Lificiguat structure

CAS No:
170632-47-0
Formula:
C19H16N2O2
Chemical Name:
Lificiguat
Synonyms:
2-Furanmethanol,5-[1-(phenylmethyl)-1H-indazol-3-yl]-;5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol;YC 1;YC 1 (pharmaceutical);1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole;Lificiguat;1-Benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole;[5-(1-Benzyl-1H-indazol-3-yl)-furan-2-yl]-methanol;[5-(1-Benzylindazol-3-yl)furan-2-yl]methanol
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Lificiguat is a member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation. It has a role as an antineoplastic agent, a soluble guanylate cyclase activator, an apoptosis inducer, a platelet aggregation inhibitor and a vasodilator agent. It is a member of indazoles, a member of furans and an aromatic primary alcohol.

Lificiguat Basic Attributes

Molecular Weight：

304.3 g/mol

Exact Mass：

304.34

UNII：

515CC1WPTE

NSC Number：

728165

DSSTox ID：

DTXSID70165635

Characteristics

PSA：

51.2 Å²

Melting Point：

110-112 °C

Drug Information

MeSH：

Compounds or factors that act on a specific enzyme to increase its activity. (See all compounds classified as Enzyme Activators.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

MeSH Entry Terms：

3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole

Computed Properties

Molecular Weight:304.3
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:304.121177757
Monoisotopic Mass:304.121177757
Topological Polar Surface Area:51.2
Heavy Atom Count:23
Complexity:386
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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