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Oxyphenonium

Oxyphenonium structure

Oxyphenonium 

structure
  • CAS No:

    14214-84-7

  • Formula:

    C21H34NO3

  • Chemical Name:

    Oxyphenonium

  • Synonyms:

    Ethanaminium,2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]-N,N-diethyl-N-methyl-;Ammonium,diethyl(2-hydroxyethyl)methyl-,α-phenylcyclohexaneglycolate (ester);Ethanaminium,2-[(cyclohexylhydroxyphenylacetyl)oxy]-N,N-diethyl-N-methyl-;2-[(2-Cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]-N,N-diethyl-N-methylethanaminium;Oxyphenonium;2-[[Cyclohexyl(hydroxy)phenylacetyl]oxy]-N,N-diethyl-N-methylethanaminium;105106-62-5;58875-49-3

Description

Solid


2-(2-cyclohexyl-2-hydroxy-1-oxo-2-phenylethoxy)ethyl-diethyl-methylammonium is an acylcholine.|A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect.

Oxyphenonium Basic Attributes

348.5 g/mol

348.25386895 g/mol

215-801-2

DTXSID8048571

A - Alimentary tract and metabolism

Characteristics

46.5 Ų

0.17

191.5°C

1.36e-04 g/L

Toxicity

93% bound to albumin

Drug Information

For the treatment of visceral spasms

Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Oxyphenonium is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).

2-((Cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methylethanaminium

Oxyphenonium Use and Manufacturing

Pharmaceuticals

Computed Properties

Molecular Weight:348.5
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:348.25386895
Monoisotopic Mass:348.25386895
Topological Polar Surface Area:46.5
Heavy Atom Count:25
Formal Charge:1
Complexity:409
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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